Holy Mary Institution was established in Feb 1948 on the insistent request from Rev. Fr. Roch, the then parish priest of Our Lady of Good Health Shrine In Khairatabad and with the kind permission of his Lordship Rt. Rev. D. Vismara, Bishop of Hyderabad.
Sr. Josephine Pedoia was put in charge of the dispensary. Sr. Lorenzina Colaco was appointed as the Headmistress of the new born school which at the initial stage was in a small tin shed in the parish church premises to cater to the moral, physical and intellectual growth of the children. Despite hard times in the beginnings of the first community of three Sisters Sr. Josephine Pedoia, Sr. Lorenzina Colaco and Sr. Colette Antony went ahead trusting in God's providence to open a School and Dispensary to cater to the needs of the poor people of Saifabad – A forlorn village in Hyderabad city.
The Sisters began the school by gathering the children from the CHINTAL BASTI SLUMS and the POLICE BAND QUARTERS. There were 50 Children on the 1st day. They varied in age - from 5 to 15 years - Speaking Urdu, Tamil and English. Steadily the number increased to 150 comprising of various castes and creeds.
The then Inspectress - Mrs. Sophia was invited for inspection. She expressed that the school looks like Shanti Niketan. With her fine report, approached the Education Department for recognition and grant in-aid. By March 1949 we got the permanent recognition and grant in-aid of Rs. 4444/- for one year.